Tuesday, January 31, 2012

TiVo Premiere Elite


The TiVo Premiere Elite ($499.99 list) is the souped-up version of the TiVo Premiere DVR ($299.99, 3.5 stars), with a 300-hour HD video capacity and two more TV tuners for the ability to record four simultaneous programs. Like the TiVo Premiere XL, the Premiere Elite is THX certified and comes with an upgraded remote (but not the slide-out QWERTY model). It?s a definite upgrade for current TiVo users, but is it compelling enough to bring more TiVo users into the fold? The outlook isn't so good, compared to DVRs from cable companies, which continue to improve over time.

Design and Features
The TiVo Premiere Elite looks almost identical to the previous TiVo Premiere, built into the same style chassis as the previous model. There are a few differences from the previous version, though. There are four lights, which glow red to show that each of the four tuners are recording a program. You can record up to four programs simultaneously, which are decoded by the mutli-stream CableCARD the TiVo Premiere Elite now requires. Previous models allowed you to record over the air HDTV broadcasts in addition to digital cable, but the Premiere Elite is a strictly digital cable-only model; TiVo has removed the RF tuner and its connector to make room for the added digital tuners. Over-the-air HDTV viewers will want the regular Premiere or Premiere XL.

If you?ve set up a TiVo HD or previous TiVo Premiere before, you know the drill: Call your cable company to get a multi-stream CableCARD, either wait for the tech to show up or install the CableCARD yourself, and hope it pairs up successfully. Once activated in your TiVo Premiere Elite and once the DVR is hooked up to your home Internet connection, the DVR will download the program guide and take you through the rest of the setup. The TiVo Premiere Elite has an Ethernet port, but you?ll need to buy a TiVo WiFi adapter ($60-$90) if you don?t have a wired connection in your TV room. All the same features are here: TiVo Search; links to Netflix, Blockbuster, Hulu Plus, Pandora, You Tube, and Amazon Instant Video; and the trademark beeps and boops from the TiVo interface. Think of the current group of TiVo DVRs as a mash-up of a cable DVR and the sort of streaming media set top box like the Apple TV ?($99, 4 stars) or the Roku LT ($49, 4 stars).

The TiVo Premiere Elite comes with a 2TB hard drive, which is good for up to 300 hours of HD video, which is an increase from 45 hours for the TiVo Premiere, and 150 hours for the TiVo Premiere XL. Like the TiVo Premiere XL, the Premiere Elite comes with the TiVo Glo remote, not the keyboard-equipped TiVo Slide ($60). The TiVo Slide is a better fit for the DVR junkie who needs to search for programming with the on-screen interface. Truly hardcore TiVo users can download the free TiVo app for their handheld device like an iPad, iPhone, or Android phone: The app replicates the search and remote functions on your handheld, including managing the recorded programs list on your TiVo Premiere Elite. The touch-screen keyboard on your iPhone or Samsung Galaxy S II will be handier than using the on-screen keyboard and TiVo Glo remote on your HDTV. However, you can?t view live TV or the recordings from your TiVo on your iPad/iPhone/Android device. You?ll still need to use a separate place-shifting device for remote viewing over WiFi or 3G.

Competitors From the Cable Company and Elsewhere
The cable companies have caught up to and some cases surpassed TiVo. TiVo?s interface now mostly takes advantage of the extra real estate and resolution of a HDTV screen, though there are still elements in standard definition. The user interface screens on digital cable DVRs like those from Verizon FIOS are fully HD optimized.

More pressing are features like FIOS? DVR apps and Cablevision/Time Warner?s viewing apps on devices like the iPad and Android smartphones. On the FIOS side, the DVR Manager app gives you listings of what?s scheduled and already recorded on your home DVRs, regardless if you?re home or on a 3G network. Need more room to record the next American Idol on your home DVR, but you?re in Des Moines? No problem with FIOS or the other cable companies, just delete those old episodes of Pan Am. In the TiVo app, you have to be physically in range of your home Wi-Fi network to see the recorded list and manage recordings, which means you can only schedule future recordings remotely, not delete existing programs. On the Time Warner and Cablevision side, things are even better when you consider that the TWC app and Optimum app allow you to view live TV as well as on-demand videos on your iPad on your home network. TiVo users need a place-shifting device like a Slingbox to do the same thing, even in your own home. Multi-room viewing was once unique to TiVo, but Cable DVRs now support multi-room viewing, letting you view programs recorded in the living room while you?re in the bedroom.? And with TiVo, there are issues with multi-room viewing and copy-protected content, which could apply to many of the programs you're recording.

Last I checked, most cable companies even let you exchange a broken DVR for free even if the DVR itself is 5 years old. Unfortunately, the TiVo DVR warranty only lasts one year for parts, 90 days for labor, with an option for 2-years parts/labor for $30 and 3 years for $40.? Last, but not least, you?ll still need to subscribe to TiVo, which added to the monthly rental for the CableCARD, equals or surpasses the monthly rental fee for a cable company DVR. TiVo curently charges $19.95 a month, so if you add the $2-5 monthly rate for the CabelCARD, you may pay less in fees on a cable company DVR. Sure, you can purchase a lifetime subscription for $499.99, but that's per TiVo DVR, and is subject to the continued good health of TiVo Inc. If you want Netflix or You Tube on your HDTV as well and your HDTV doesn't already support it, check if there?s a free HDMI port on your TV, then get an Apple TV or Roku; it?s less than $100, and you won?t need to pay a monthly fee to Apple.

The TiVo Premiere Elite is an improved device for an ultimately shrinking market: the hardcore TiVo user. It will give the TiVo fan a lot to crow about while recording 300 hours of HD on four channels simultaneously, but the DVR is unlikely to add brand new customers to the TiVo fold. It's so tied to digital cable that it is unlikely to sway the non-TiVo user from renting a much more convenient and similar HD DVR for much less money. Why buy a TiVo DVR when the cable company DVR is the same amount of money or less, and lets you better manage it with your smartphone or tablet? Five years ago, TiVo had a perceptibly insurmountable lead on the competition. Now that gap is bridgeable by a toddler in brand new shoes.

More Digital Video Recorder reviews:
??? TiVo Premiere Elite
??? TiVo (for iPad)
??? Monsoon Multimedia Vulkano
??? Dish Network ViP922 SlingLoaded DVR
??? TiVo Premiere
?? more

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Polls show Romney surging ahead of Gingrich in Florida (reuters)

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Monday, January 30, 2012

Processes leading to acute myeloid leukemia discovered

ScienceDaily (Jan. 30, 2012) ? Researchers at UC Santa Barbara have discovered a molecular pathway that may explain how a particularly deadly form of cancer develops. The discovery may lead to new cancer therapies that reprogram cells instead of killing them. The findings are published in a recent paper in the Journal of Biological Chemistry.

The UCSB research team described how a certain mutation in DNA disrupts cellular function in patients with acute myeloid leukemia (AML). The researchers were prompted to study this process by another research team's discovery that AML patients have a mutation in a certain enzyme, which was reported in the New England Journal of Medicine. The enzyme is a protein called DNMT3A, which leads to changes in how the DNA of AML patients is methylated, or "tagged." Norbert Reich, professor in the Department of Chemistry and Biochemistry at UCSB, was already studying that particular enzyme with his research group, so they began to study the disease process of AML at the cellular level.

Reich explained that tagging is a way of reading DNA at the cellular level. This falls within an area of study called epigenetics, a process that occurs "on top" of genetics. Each person has approximately 200 types of cells, all with the same DNA, and these must be controlled in different ways. "There is an enzyme -- a protein -- that tags DNA and controls which of the genes in your cells, your DNA, gets turned on and off," said Reich. "So you have 20,000 genes, and you have to control them differently in your brain than in your liver."

Reich explained that there is current interest in this broader field of epigenetics as a direction for the treatment of cancer. "There's definitely the idea that this may be a new way of developing therapeutics, because you don't have to kill the cancer cell," said Reich. "Almost every cancer therapy that's out there works on the principle that a cancer cell needs to be killed."

With epigenetics, instead of only having DNA sequence coding for certain genes, there is an epigenetic process, with another layer of information on top of the genetic process. In this case, that information is the tagging by the methyl groups.

"If you really think about it, this is part of the answer as to how your cells can be so different and yet they all have the same DNA," said Reich. "You have the same genome in every one of your cells, but you do not have the same epigenome, which is basically the methylation pattern, the tagging pattern. That is different in every type of your cells. And the way this relates back to cancer, with leukemia, in those patients, the tagging is messed up. The patterns are not correct. Our big contribution to that is we've explained how the mutations in the enzyme could lead to that disruption of the tagging pattern."

The UCSB group developed a test to demonstrate that the mutant enzymes in AML can only work on DNA for short distances. As a result, the precise methylation patterns of a healthy cell are disturbed, resulting in genes being turned on at the wrong place and time, which in turn can initiate the growth of cancerous cells.

The team found that the mutation AML patients have causes a certain complex of four proteins to be disrupted. "The surprise was that the disruption doesn't stop the enzyme from being active; it doesn't stop the enzyme from tagging the DNA," said Reich. "Instead, it stops the way it can do it. Instead of going to your DNA and tagging an entire region of chromosome, it goes there, does one thing, and leaves. That process, that change, is what we see in the AML patients. So we think we have a molecular explanation for this disease."

Reich said that the currently prescribed drug Vidaza works by affecting the same enzyme that is mutated in AML. There is interest in the pharmaceutical industry in developing other therapeutics to target the enzymes responsible for tagging the DNA. These epigenetic inhibitors would reprogram rather than kill the cell.

Traditional cancer therapies use radiation and chemotherapy to remove or kill cancer cells. "The problem with that is that cancer cells are often very subtly different from normal cells," said Reich. "So you have one of the most difficult therapeutic challenges known to man, which is to distinguish between two human cells -- one that's cancerous and one that's not. Instead of killing the cell, the notion is that if you could just reprogram the cell, then it goes back to being normal. You intercept the cancer development. This is still an aspiration; it hasn't been achieved really, but that's what attracts people to the field of epigenetic-based therapies, because of the prospect of not having to kill cells."

Celeste Holz-Schietinger and Douglas Matje, both graduate students working in the Reich lab, are the first and second authors of the paper.

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The above story is reprinted from materials provided by University of California - Santa Barbara.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. C. Holz-Schietinger, D. M. Matje, M. F. Harrison, N. O. Reich. Oligomerization of DNMT3A Controls the Mechanism of de Novo DNA Methylation. Journal of Biological Chemistry, 2011; 286 (48): 41479 DOI: 10.1074/jbc.M111.284687

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/01/120130094349.htm

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Sunday, January 29, 2012

UN nuclear team arrives in Iran (AP)

TEHRAN, Iran ? A U.N. nuclear team arrived in Tehran early Sunday for a mission expected to focus on Iran's alleged attempt to develop nuclear weapons.

The U.N. nuclear agency delegation includes two senior weapons experts ? Jacques Baute of France and Neville Whiting of South Africa ? suggesting that Iran may be prepared to address some issues related to the allegations.

The delegation from the International Atomic Energy Agency is led by Deputy Director General Herman Nackaerts, who is in charge of the Iran nuclear file. Also on the team is Rafael Grossi, IAEA chief Yukiya Amano's right-hand man.

In unusually blunt comments ahead of his arrival in Tehran, Nackaerts urged Iran to work with his mission on probing the allegations about Iran's alleged attempts to develop nuclear weapons, reflecting the importance the IAEA is attaching to the issue.

Tehran has refused to discuss the alleged weapons experiments for three years, saying they are based on "fabricated documents" provided by a "few arrogant countries" ? a phrase authorities in Iran often use to refer to the United States and its allies.

Ahead of his departure, Nackaerts told reporters at Vienna airport he hopes Iran "will engage with us on all concerns."

"So we're looking forward to the start of a dialogue," he said: "A dialogue that is overdue since very long."

In a sign of the difficulties the team faces and the tensions that surround Iran's disputed nuclear program, a dozen Iranian hard-liners carrying photos of slain nuclear expert Mostafa Ahmadi Roshan were waiting at Tehran's Imam Khomeini airport early Sunday to challenge the team upon arrival.

That prompted security officials to whisk the IAEA team away from the tarmac to avoid any confrontation with the hard-liners.

Iran's official IRNA news agency confirmed the team's arrival and said the IAEA experts are likely to visit the underground Fordo uranium enrichment site near the holy city of Qom, 80 miles (130 kilometers) south of the capital, Tehran.

During their three-day visit, the IAEA team will be looking for permission to talk to key Iranian scientists suspected of working on a weapons program, inspect documents related to such suspected work and secure commitments from Iranian authorities to allow future visits to sites linked to such allegations. But even a decision to enter a discussion over the allegations would be a major departure from Iran's frequent simple refusal to talk about them.

The United States and its allies want Iran to halt its enrichment of uranium, which they worry could eventually lead to weapons-grade material and the production of nuclear weapons. Iran says its program is for peaceful purposes, such as generating electricity and producing medical radioisotopes to treat cancer patients.

Iran has accused the IAEA in the past of security leaks that expose its scientists and their families to the threat of assassination by the U.S. and Israel.

Iranian state media say Roshan, a chemistry expert and director of the Natanz uranium enrichment facility in central Iran, was interviewed by IAEA inspectors before being killed in a brazen bomb attack in Tehran earlier this month.

Iranian media have urged the government to be vigil, saying some IAEA inspectors are "spies," reflecting the deep suspicion many in Iran have for the U.N. experts sent to inspect Iran's nuclear sites.

___

AP writer George Jahn contributed to this report from Vienna.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/ap/20120129/ap_on_re_mi_ea/iran_nuclear

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"The Artist" director Michel Hazanavicius wins DGA award (Reuters)

LOS ANGELES (Reuters) ? "The Artist" director Michel Hazanavicius was named the year's best feature film director by the Directors Guild of America on Saturday, further positioning the silent movie-era romance as a frontrunner for Oscars.

The movie about a fading star whose career is eclipsed by the woman he loves just as talkies are putting an end to silent pictures has been a critical darling throughout the Hollywood's current awards season.

"This is really touching and moving for me," said French director Hazanavicius upon accepting his award at the Grand Ballroom adjacent to the Kodak Theatre where the Oscars, the film industry's highest honors, will be given out on February 26.

"It's maybe the highest recognition I could hope for," he said.

The DGA Awards are a key indicator of who may win Academy Awards next month because only six times since the DGA began handing out annual honors in 1948 has the its winner failed to also be named best director by Oscar voters.

More important, there is a long history among members of the Academy of Motion Picture Arts and Sciences, which gives out the Oscars, to give their Academy Award for best film to the movie made by the winner of best director.

The next stop in the race for Oscars is Sunday's Screen Actors Guild awards in Los Angeles where "The Artist" will look to extend its streak of victories, including a Golden Globe for best film musical or comedy and honors from critics groups.

The DGA also gives out other awards, including one for best film documentary, which went to James Marsh for "Project Nim."

Among TV award winners, Patty Jenkins was given the DGA trophy for best drama series for the pilot episode of "The Killing" and Robert B. Weide took home the DGA award for best comedy series for an episode of "Curb Your Enthusiasm."

(Reporting By Bob Tourtellotte; Editing by Bill Trott)

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/nm/20120129/en_nm/us_dgaawards

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Saturday, January 28, 2012

AP Exclusive: Barrier proposed as Israel border (AP)

RAMALLAH, West Bank ? Israel is proposing to essentially turn its West Bank separation barrier into the border with a future state of Palestine, two Palestinian officials said Friday, based on their interpretation of principles Israel presented in talks this week.

The officials said Israeli envoy Yitzak Molcho told his Palestinian counterpart that Israel wants to keep east Jerusalem and consolidate Jewish settlements behind the separation barrier, which slices close to 10 percent off the West Bank. They spoke on condition of anonymity, citing strict no-leaks rules by Jordanian mediators.

The proposal would fall short of what the Palestinians seem likely to accept, especially because it would leave Jerusalem on the "Israeli" side of the border.

But it would also mark a significant step for Israeli Prime Minister Benjamin Netanyahu, who has spent most of his career as a staunch opponent of Palestinian independence.

And if talks advance in such a direction, it could also spell the end for his nationalist coalition, where key members would consider the abandonment of most of the West Bank ? a strategic highland and biblical heartland ? an unforgivable betrayal.

Israel has confirmed that it presented principles this week for drawing a border with a Palestinian state. But the politically charged nature of the talks ? even though they were held at a relatively low level, below that of Cabinet ministers ? was reflected in the guarded refusal by any top official to discuss details.

An Israeli government official said that as far as he knew, the information was incorrect, but declined to elaborate or go on the record, citing Jordan's demand for discretion.

Deputy Prime Minister Dan Meridor, one of the closest Cabinet ministers to Netanyahu, said he has been supporting such an offer for months, and that Israel should concentrate on preserving the large West Bank settlement blocs, close to the pre-1967 border. But he could not confirm whether the offer was in fact made.

"I do not know if (Molcho) said these words exactly, but it would be great," Meridor told The Associated Press.

The Palestinian officials ? one a senior member of the leadership ? said Molcho told the Palestinians that Israel wants to leave peacefully beside a Palestinian state.

It would be the most detailed offer yet from Netanyahu on how much he wants to keep of the lands Israel captured in the 1967 Mideast War ? the West Bank, Gaza and east Jerusalem.

The Palestinians want to establish their state in virtually all of these lands ? although they do seem ready to accept minor adjustments, through land swaps in which Israel keeps some of the largest settlements.

Palestinian President Mahmoud Abbas is certainly unlikely to consider a proposal that keeps east Jerusalem under Israeli control. The eastern sector of the city is home to key Jewish, Muslim and Christian sites.

And Israel's position, as described by the Palestinians, is less than what was offered by Netanyahu's predecessors, Ehud Barak and Ehud Olmert, who were willing to discuss a partition of Jerusalem as well.

About half a million Israelis settled in east Jerusalem and the West Bank after 1967, including tens of thousands east of the barrier.

Israel started building the barrier in 2002, in the midst of a Palestinian uprising that included scores of deadly attacks by Palestinian militants who crossed from the West Bank into Israel and blew themselves up among civilians.

Israelis have generally credited the barrier ? along with other punitive measures ? with stopping the spate of incursions several years ago.

However, it was routed in a way that raised questions about Israel's claim that it was a temporary security measure ? weaving through the West Bank, looping wide around some settlements to leave room for expansion, and looking very much like a border a future Israeli government might argue for. The Palestinians condemned it from the start as a land grab.

The Palestinian officials also said that Molcho portrayed the Jordan Valley, which makes up about one-fourth of the West Bank and borders Jordan, as a strategic Israeli security asset. However, that wording suggests less than a demand for firm territorial control.

Netanyahu has said he wants a continued Israeli presence on the eastern border of a future Palestinian state as part of any peace deal.

Netanyahu has long argued Israel needs the area as a security buffer ? protection against possible attack from the east.

The 1994 peace treaty with Jordan eased this concern ? but the Arab Spring has given it new life: although it is almost never discussed by officials, mindful of riling Jordan, many in Israel ponder a nightmare scenario in which the Jordanian monarchy falls to Israel's enemies, who then pour weapons and militants into the West Bank, reaching within miles (kilometers) from its major cities.

A senior Israeli military official said last week the Israeli army had to consider in its planning the possibility of heightened threats from east of the West Bank.

Israeli officials have said any presence in the Jordan Valley could be reviewed over time.

Abbas, meanwhile, is under growing pressure from the Quartet of Mideast mediators ? the U.S., the U.N., the EU and Russia ? to continue the talks with Israel, which began earlier this month. The Quartet had asked the sides to present detailed proposals on borders and security arrangements.

The Palestinians argue that the period set aside for the contacts ended Thursday, or three months after the Quartet issued its marching orders. Israel says the intention was to have three months of talks, and so wants meetings to continue.

Abbas will consult Monday with senior officials from the Palestine Liberation Organization and his Fatah movement. Later next week, he will also seek advice from the Arab League.

___

Perry reported from Tel Aviv, Israel.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_re_mi_ea/ml_israel_palestinians

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Western Digital MyBook Thunderbolt Duo eyes-on at Macworld 2012 (video)

Here at Macworld 2012, Western Digital demoed a preview of their essentially finished, yet not final, MyBook Thunderbolt Duo. Scheduled to ship in Q1 for an "aggressive price," the unit plays host to two 3.5-inch drives, which'll come stuffed from the factory in either 4TB (2x 2TB) or 6TB (2x 3TB) configurations. On the outside, you're looking at the MyBook aesthetic you either love or loathe, but around back you'll find all connectivity has been gutted, save for power and two Thunderbolt ports. The latter means that up to six can be daisy-chained off one interconnect, which when setup in RAID 0 equates to rather speedy transfers, like 700MB/sec reads and 500MB/sec writes in the four-unit demonstration configuration we toyed with. And it's future proof too, as there's a door up-top which enables plebes to swap drives should the need arise. We'll keep an ear out for pricing, but until that day arrives, peep them in the gallery below, or in video form after the break.

Continue reading Western Digital MyBook Thunderbolt Duo eyes-on at Macworld 2012 (video)

Western Digital MyBook Thunderbolt Duo eyes-on at Macworld 2012 (video) originally appeared on Engadget on Thu, 26 Jan 2012 16:47:00 EDT. Please see our terms for use of feeds.

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Friday, January 27, 2012

Multiple births lead to weight gain, other problems for mouse moms and offspring

ScienceDaily (Jan. 26, 2012) ? Women have long bemoaned the fact that as they have more children, their weight gain from pregnancy becomes more difficult to lose. A new study using a mouse model that mimics the human effects of multiparity (giving birth more than once) has found that mouse moms who gave birth four times accrued significantly more fat compared to primiparous females (those giving birth once) of similar age. The study also found significantly more inflammation in the livers of multiparous animals. Multiparity's effect also extended to the male offspring, who showed significant weight gain during adulthood.

Their primiparous counterparts did not, despite similar levels of food consumption. The findings are contained in a study entitled "Multiparity Leads to Obesity and Inflammation in Mothers and Obesity in Male Offspring," and appear in the American Journal of Physiology -- Endocrinology and Metabolism, published by the American Physiological Society.

Methodology

Researchers at the University of Cincinnati designed the study in two parts. In the first part, they established the mouse model that mimics multiparity-induced obesity in humans. In the second part, they examined male offspring of the multiparous females.

The researchers compared one group of mice that gave birth four times with a second group of mice that gave birth only once, some of these at the same age that the first group had its fourth litter and some at a younger age.

The researchers weighed these animals and assessed the size of their fat deposits. They also performed glucose tolerance tests in all the mice and measured biochemical markers of inflammation. Additionally, the researchers performed similar tests in the male offspring of primiparous and multiparous mice, and measured weight, fat deposits, and glucose tolerance. They also measured the expression levels of various genes involved in storing versus using fat.

Results

The first part of the study showed that giving birth multiple times was a significant contributor to obesity regardless of age, with mice who gave birth multiple times being up to 45 percent heavier than those who had a single litter at the same age that the first animals had their fourth. The multiparous animals had fat deposits several times larger than those in typically-mated primiparous mice, as well as significantly larger glucose spikes after meals, a warning sign for diabetes. Multiparous moms also showed elevated markers for inflammation in numerous body tissues, a condition linked to heart disease, diabetes, cancer, and a variety of other diseases, as compared to the primiparous mice as well as age-matched females fed a high fat diet.

The second part of the study revealed that male offspring of multiparous mice weighed as much as 40 percent more than the male offspring of primiparous mice, despite eating no more food. Interestingly, the differences became apparent when the offspring were older, suggesting that excess energy was stored as fat only after growth rate slowed down. When the researchers examined genes responsible for storing versus using fat, the offspring of multiparous animals appeared to use less fat compared to those of the primiparous animals.

Importance, Implications of the Findings

These findings confirm that in mice, as in humans, giving birth multiple times, regardless of age, can lead to significant weight gain, and inflammation. The results also support the theory that multiple pregnancies induce metabolic stresses on females that have heritable consequences and may be part of an obesity cycle between mothers and offspring.

The authors suggest that finding effective ways to help women lose weight between pregnancies will assist in maintaining their health and that of their children, though additional interventions will likely be required as multiple pregnancies appear to have an adverse effect on women that is independent of her fat mass. "The current studies are important in supporting a healthier, less obese population in that we have defined specific metabolic pathways that are likely involved in the programming of obesity and can be targeted in either the mother or her offspring," the authors say.

The study was conducted by Sandra R. Rebholz, Thomas Jones, Katie T. Burke, Anja Jaeschke, Patrick Tso, David A. D'Alessio, and Laura A. Woollett, all of the University of Cincinnati College of Medicine.

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Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. L. Rebholz, T. Jones, K. T. Burke, A. Jaeschke, P. Tso, D. A. D'Alessio, L. A. Woollett. Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. AJP: Endocrinology and Metabolism, 2011; DOI: 10.1152/ajpendo.00487.2011

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/01/120126223605.htm

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Thursday, January 26, 2012

Lakers get last word over Clippers in inner-city clash (Reuters)

LOS ANGELES (Reuters) ? The inner-city battle for Los Angeles added another feisty chapter as the Lakers battled to a 96-91 win over the Clippers on Wednesday to reassume their top billing status.

In a duel that featured a number of technical fouls and minor skirmishes, Kobe Bryant started passively but scored 12 of his 24 points in the pivotal fourth quarter to lead the Lakers to victory.

Pau Gasol had 23 points and 10 rebounds and the Lakers (11-8) ended their three-game losing streak with a satisfying victory that ended with Bryant and Gasol exchanging heated words with Clippers leader Chris Paul.

The Lakers trailed by a slim margin for much of the game but Bryant made a three-pointer midway through the fourth quarter to give the home team their first lead since the opening minute, and they held on to spoil the return of Paul.

Paul, whose off-season trade to the Clippers turned them into a legitimate rival of the Lakers, looked rusty after missing five games with a hamstring injury and finished with four points and 12 assists.

He was originally injured in a Clippers' victory over the Lakers on January 14 which signaled their arrival as peers.

This time, the Clippers (9-6) fell back despite leading by nine early in the third and getting 26 points and nine rebounds from Blake Griffin.

(Editing by John O'Brien)

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/nm/20120126/sp_nm/us_nba_lakers

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US military raid in Somalia frees American, Dane (AP)

MOGADISHU, Somalia ? U.S. Navy SEALs parachuted into Somalia under cover of darkness early Wednesday and crept up to an outdoor camp where an American woman and Danish man were being held hostage. Soon, nine kidnappers were dead and both hostages were freed.

President Barack Obama authorized the mission by SEAL Team 6 two days earlier, deploying the same unit that killed Osama bin Laden last year. Minutes after the president gave his State of the Union address to Congress he was on the phone with the American's father to tell him his daughter was safe.

The Danish Refugee Council confirmed the two aid workers, American Jessica Buchanan and Poul Hagen Thisted, a Dane, were "on their way to be reunited with their families."

Buchanan, 32, and Thisted, 60, were working with a de-mining unit of the Danish Refugee Council when gunmen kidnapped the two in October.

The raiders came in quickly, catching the guards as they were sleeping after having chewed the narcotic leaf qat for much of the evening, a self-described pirate who gave his name as Bile Hussein told The Associated Press by phone. Hussein said he was not present at the site but had spoken with other kidnappers who were, and that they told him nine kidnappers had been killed in the raid and three were "taken away."

The hostage rescue was carried out by the same SEAL unit, SEAL Team 6, behind the operation in Pakistan last May that killed bin Laden, two U.S. officials said on condition of anonymity to discuss the operation.

One official said that the team parachuted into the area before moving on foot to the target. The raid happened near the Somali town of Adado.

New intelligence emerged last week that Buchanan's health was deteriorating rapidly, so Obama directed his security team to develop a rescue plan, according to a senior administration official who was not authorized to speak publicly. A Danish Refugee Council official, Mary Ann Olsen, said that Buchanan was "not that ill" but needed medicine.

"As Commander-in-Chief, I could not be prouder of the troops who carried out this mission, and the dedicated professionals who supported their efforts," Obama said in a statement released by the White House. "The United States will not tolerate the abduction of our people, and will spare no effort to secure the safety of our citizens and to bring their captors to justice."

A Western official said the rescuers and the freed hostages flew by helicopter to a U.S. military base called Camp Lemonnier in the Horn of Africa nation of Djibouti. Both officials spoke on condition of anonymity because the information had not been released publicly. Defense Secretary Leon Panetta visited Camp Lemonnier just over a month ago. A key U.S. ally in this region, Djibouti has the only U.S. base in sub-Saharan Africa. It hosts the military's Combined Joint Task Force-Horn of Africa.

The timing of the raid may have been made more urgent by Buchanan's medical condition. The Danish Refugee Council had been trying to work with Somali elders to win the hostages' freedom but had found little success.

"One of the hostages has a disease that was very serious and that had to be solved," Danish Foreign Minister Villy Soevndal told Denmark's TV2 channel. Soevndal did not provide any more details. Soevndal congratulated the Americans for the raid.

The Danish Refugee Council said both freed hostages are unharmed "and at a safe location." The group said in a separate statement that the two "are on their way to be reunited with their families."

Olsen informed Thisted's family of the successful military operation and said "they were very happy and incredibly relieved that it is over." Olsen said the two freed hostages were in Djibouti and would soon be moved to a "safe haven." She said Buchanan does not need to be hospitalized.

"One of the first things Poul and Jessica were able to do was to call their families and say they were freed," Olsen said. "They will be reunited with their families as quickly as possible," Olsen said.

The head of the Danish Refugee Council, Andreas Kamm, said he would have preferred to see the two hostages freed peacefully after working with Somali groups to win the pair's freedom, "but we're happy with the outcome. This is a day of joy indeed."

The two aid workers appear to have been kidnapped by criminals and not by Somalia's al-Qaida-linked militant group al-Shabab. As large ships at sea have increased their defenses against pirate attacks, gangs have looked for other money making opportunities like land-based kidnappings.

The Danish Refugee Council had earlier enlisted traditional Somali elders and members of civil society to seek the release of the two hostages.

"We are really happy with the successful release of the innocents kidnapped by evildoers," said Mohamud Sahal, an elder in Galkayo town, by phone. "They were guests who were treated brutally. That was against Islam and our culture ... These men have spoiled our good customs and culture, so Somalis should fight back."

Buchanan lived in neighboring Kenya before Somalia, and worked at a school in Nairobi called the Rosslyn Academy from 2007-09, said Rob Beyer, the dean of students. He described the American as quick to laugh and adventurous.

"There have been tears on and around the campus today," Beyer said. "She was well-loved by all her students."

Buchanan graduated in 2006 from Valley Forge Christian College, a small suburban Philadelphia school. The school's president, the Rev. Don Meyer, said Buchanan taught at Rosslyn as part of her studies and "fell in love with Africa."

"Ever since Jessica was captured, we all as a community have been praying for her safety and for her safe release," Meyer said. "We are also grateful that our prayers have been answered."

Buchanan and Thisted were seized in October from the portion of Galkayo town under the control of a government-allied clan militia. The aid agency has said that Somalis held demonstrations demanding the pair's quick release.

Their Somali colleague was detained by police on suspicion of being involved in their kidnapping.

The two hostages were working in northern Somalia for the Danish Demining Group, whose experts have been clearing mines and unexploded ordnance in conflict zones in Africa and the Middle East.

Several hostages are still being held in Somalia, including a British tourist, two Spanish doctors seized from neighboring Kenya, and an American journalist kidnapped on Saturday.

___

Associated Press reporters Julie Pace in Washington, Jason Straziuso in Nairobi, Kenya, Jan M. Olsen in Copenhagen, Denmark, and Patrick Walters in Philadelphia contributed to this report. Houreld reported from Nairobi and Dozier from Washington.

___

Follow Katharine Houreld at http://twitter.com/khoureld

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_re_af/af_somalia_helicopter_raid

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Wednesday, January 25, 2012

Severe Brain Injury When Young May Have Long-Term Effects (HealthDay)

MONDAY, Jan. 23 (HealthDay News) -- Although many people believe young children are extremely resilient after they are seriously hurt, the opposite may be true with traumatic brain injuries.

Two Australian studies looked at the impact of traumatic brain injury in children as young as 2 years, and found that these injuries affected cognitive function, IQ and even behavior for some time. However, the researchers also found that recovery from traumatic brain injury can continue for years after the initial injury. And, a child's home environment can positively influence recovery if the child lives in a stable, caring home.

"Many people think that the soft skull of a baby may give them some advantage because if they fall they are not likely to sustain a skull fracture. Also, because a baby's brain is growing so quickly, it seems like the brain may be able to fix an injury. In reality, the soft skull and growing brain of a baby put them at a greater risk of future problems," said the lead author of one of the studies, Louise Crowe, a postdoctoral research officer at the Murdoch Childrens Research Institute in Melbourne.

"Children with significant head injuries do recover, but they are generally slower to learn concepts, and some high-level skills are often too difficult for them," she added.

Results from both studies were released online Jan. 23 and are scheduled to appear in the February issue of Pediatrics.

By age 16, at least one in 30 children will experience a traumatic brain injury, according to background information in one of the studies. Traumatic brain injuries (TBIs) occur after a blow or bump to the head, according to the U.S. Centers for Disease Control and Prevention.

Young children -- those under 4 years old -- are particularly at risk of experiencing a traumatic brain injury, according to the CDC. Such injuries can occur from a fall, a car accident, deliberate child abuse, sports or being hit with a moving object. Fortunately, most of these injuries aren't fatal, but about one-third of children who survive a TBI will have lasting damage, report the researchers.

Very few studies, however, have followed youngsters from the time of their injury through adolescence, to assess the full effect of the brain injury.

The first study looked at 40 children between the ages of 2 and 7 who had experienced a traumatic brain injury. They were compared to 16 healthy children. The children were examined 12 months, 30 months and 10 years after the injury, according to the study.

Not surprisingly, they found that children with the most severe injuries had the worst cognitive outcomes.

But, the news wasn't all bad. Initially, while the brain was recovering from the injury, the children didn't make significant developmental gains for about three years. However, after that period, and at least up until 10 years after the injury, the children began to make some age-appropriate developmental gains.

That means that even many years after an injury, interventions and therapies for these children may be effective, said the study's lead author, Vicki Anderson, a professor in critical care and neuroscience research at the Murdoch Institute.

"Although this does not suggest that children catch up to peers, it does imply that the gap does not widen during this period," she said.

This study also found that the home environment and relationships could make a difference in a child's recovery. More stable homes with less family conflict appeared to contribute to a child's recovery.

"It's difficult to predict outcome," said Anderson. "A quality home environment and access to appropriate rehabilitation is critical to maximize outcomes. Or, the young brain is plastic, and so the better the environment, the better the outcome."

The second study, led by Crowe, followed a group of 53 children who had sustained a traumatic brain injury before they were 3 years old, and 27 non-injured children. They followed up with these children when they were between 4 and 6 years old. The average time since the injury occurred was 40 months.

Children who had moderate-to-severe TBIs scored lower on IQ tests by about seven to 10 points, according to the study. Mild traumatic brain injuries didn't seem to significantly affect IQ. However, mild and moderate-to-severe TBIs were associated with an increased risk of behavior problems.

And, as with Anderson's study, this study also found that a child's environment has an effect on cognitive function and behavior after a brain injury.

"Children from cohesive family environments and children whose parents had lower levels of stress showed better recovery," Crowe said. "Why this is so is unclear, but it may be due to a parent spending more time with their children, and children also growing up in a less stressful environment."

One expert noted that the findings make an important point.

"We still don't understand all of the factors that affect outcomes. But, these studies do give us important data. We don't necessarily want to close the door on treating these children too soon. There may still be room for improvement over time, but there are persistent deficits," said Dr. Mandeep Tamber, an assistant professor of pediatric neurosurgery at Children's Hospital of Pittsburgh.

Meanwhile, Crowe advised parents to be vigilant with young children. She said traumatic brain injuries can result from seemingly minor accidents, such as a baby rolling off of a bed or couch.

More information

Learn more about traumatic brain injuries from the U.S. Centers for Disease Control and Prevention.

Source: http://us.rd.yahoo.com/dailynews/rss/health/*http%3A//news.yahoo.com/s/hsn/20120123/hl_hsn/severebraininjurywhenyoungmayhavelongtermeffects

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Germany, France press for Greek debt deal (Reuters)

PARIS/BERLIN (Reuters) ? Germany and France pressed on Monday for a rapid deal between Greece and its private creditors that returns its soaring debt to sustainable levels and said they remained committed to a new bailout that is needed by March to avert a disastrous default.

Euro zone finance ministers are due to decide later on Monday what terms of a Greek debt restructuring they are ready to accept as part of a second rescue for Athens.

Ahead of that meeting, French Finance Minister Francois Baroin said an elusive deal to convince the banks and investment funds that own Greek debt to accept deep losses on their holdings appeared to be "taking shape."

But his German counterpart Wolfgang Schaeuble warned that any deal must help Greece cut its debt mountain to "not much more than 120 percent of GDP" by the end of the decade, from roughly 160 percent today, something many economists believe will not be achieved by the existing plan.

"The negotiations will be difficult, but we want the second program for Greece to be implemented in March so that the second tranche can be released," Schaeuble told a news conference in Paris with Baroin and the heads of the German and French central banks.

"Greece must fulfill its commitments, it is difficult and there is already a lot of delay," Schaeuble said.

After several rounds of talks, Greece and its private creditors are converging on a deal in which private bondholders would take a real loss of 65 to 70 percent on their Greek bonds, officials close to the negotiations say.

But some details of the debt restructuring, which will involve swapping existing Greek bonds for new, longer-term bonds are unresolved.

Charles Dallara, the Institute of International Finance chief who is negotiating on behalf of the private debt holders, left Athens over the weekend saying banks had no room to improve their offer.

Sources close to the talks told Reuters on Monday that the impasse centered on questions of whether the deal would return Greece's debt mountain, currently over 350 billion euros, to levels that European governments believe are sustainable.

"There will likely be an updated debt sustainability analysis that will be discussed at the Eurogroup," a banking source in Athens said, requesting anonymity. "Talks will continue this week. The aim is to have an agreement by late next Monday."

In Brussels, European Economic and Monetary Affairs Commissioner Olli Rehn said talks had been "moving well" and expressed confidence a deal could be sealed this week.

But German Chancellor Angela Merkel said there was no question of extending Greece a bridging loan if talks with the private sector dragged on further.

The euro pushed up to its highest level against the dollar in nearly three weeks on hopes for a successful debt swap.

LAGARDE DEMANDS

Speaking in Berlin not far from Merkel's Chancellery, IMF chief Christine Lagarde urged European governments to increase their financial firewall to prevent Greece's troubles from ensnaring bigger countries like Italy and Spain.

She also called on European leaders to complement the "fiscal compact" they agreed last month with some form of financial risk-sharing, mentioning euro zone bonds or bills, or a debt redemption fund as possible options.

Berlin opposes those steps and Merkel told a news conference with the Belgian prime minister that it was not the time to debate an increase in the euro zone's bailout funds -- the European Financial Stability Facility (EFSF) and its successor, the 500 billion euro European Stability Mechanism (ESM).

"I don't think it is right to do one new thing then do another, let's get the ESM working," Merkel said, reiterating that Germany was prepared to accelerate the flow of capital into the ESM ahead of its planned introduction in mid-2012.

Italian Prime Minister Mario Monti, who has complained openly that his reform efforts have not been recognized by the markets, is reportedly pushing for the rescue fund to be doubled to 1 trillion euros. Lagarde stopped short of advocating that, saying: "I am not saying double it."

The more immediate worry is Greece. Without the second bailout from the euro zone and the International Monetary Fund, Athens will not be able to pay back 14.5 billion euros in maturing bonds in March, triggering a messy default that would hurt the entire euro zone and send tremors beyond the 13-year old single currency bloc.

DETERIORATION

Euro zone leaders agreed in October that the second bailout would total 130 billion euros, if private bondholders forgave half of what Greece owes them in nominal terms.

But Greek economic prospects have deteriorated since then, which means either euro zone governments or investors will have to contribute more than thought.

A key sticking point is the coupon, or interest rate, the new Greek bonds would carry. Officials said the new bonds are likely to be 30 years in maturity and carry a progressively higher coupon, which would average out at around 4 percent.

"The euro zone ministers will examine the proposal and say whether we have a deal. If they say we don't, we're back to the negotiating table," a banking source close to the talks said.

Progress will be presented to euro zone ministers by Greek Finance Minister Evangelos Venizelos.

After dealing with Greece, euro zone ministers will choose a replacement for European Central Bank Board member Jose Manuel Gonzales Paramo, whose term ends in May.

The 17 ministers of the euro zone will then be joined by 10 ministers from the other European Union countries to finalize a treaty setting up the euro zone's permanent bailout fund, the ESM.

The 27 EU finance ministers will also prepare the final draft of another treaty to sharply tighten fiscal discipline in the euro zone, called the "fiscal compact," that is designed to ensure another sovereign debt crisis cannot happen in future.

EU leaders are to sign off on both treaties at a summit on January 30, allowing the ESM to become operational in July.

(Additional reporting by Stephen Brown and Alexandra Hudson in Berlin, Leigh Thomas in Paris, Lefteris Papadimas and Ingrid Melander in Athens; Writing by Noah Barkin and Jan Strupczewski, editing by Mike Peacock)

Source: http://us.rd.yahoo.com/dailynews/rss/religion/*http%3A//news.yahoo.com/s/nm/20120123/ts_nm/us_eurozone_ministers

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Tuesday, January 24, 2012

Kuwait: Envoy to US during Iraq invasion dies (AP)

KUWAIT CITY ? Sheik Saud Al Nasser Al Sabah, who served as Kuwait's ambassador to the U.S. during Iraq's 1990 invasion of the oil-rich country and the American-led war to oust Saddam Hussein's forces, has died, a government-backed newspaper reported Sunday. He was 68.

Al-Qabas said the former diplomat died Saturday. It gave no cause of death.

A member of Kuwait's royal family, Sheik Nasser was a leading voice calling for international help during Iraq's occupation. But he was forced to defend his tactics when it was revealed that his then-teenage daughter, Nayirah, told U.S. lawmakers in October 1990 that she had witnessed Iraqi soldiers yank newborn babies from incubators. Several rights groups later questioned the account, which helped galvanize U.S. public opinion in favor of war.

A statement Sunday from former President George H. W. Bush called Sheik Nasser a "trusted partner" during the occupation and the U.S.-led war in 1991 that drove Saddam's military from Kuwait.

"Throughout that defining ordeal, he stood proudly with the United States as our coalition ejected Saddam's forces from Kuwaiti soil and upheld international law," said Bush's statement from Houston. "He was truly a good man, and a joy with whom to work."

Sheik Nasser served as Kuwait's envoy to Washington from 1981 to 1992. He later served in Kuwait's government as information minister and oil minister.

In the past decade, he played an elder statesmen's role with close ties to the White House and U.S. officials.

He also was a strong opponent of anti-Western views by Islamic hard-liners in Kuwait. In 2003, he joined other Kuwaiti leaders in endorsing the U.S. invasion of Iraq and called it the "beginning of the end" for Muslim extremists.

Al-Qabas newspaper said a funeral was scheduled for Sunday.

Source: http://us.rd.yahoo.com/dailynews/rss/iraq/*http%3A//news.yahoo.com/s/ap/20120122/ap_on_re_mi_ea/ml_obit_kuwait_ambassador

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Monday, January 23, 2012

Wall Street stalls at open after big run (Reuters)

NEW YORK (Reuters) ? Stocks were little changed in early trading on Monday after equities posted their best week in a month as the euro zone debt crisis and the economy showed signs of stabilizing.

Germany and France pressed for a rapid deal between Greece and its private creditors and said they remained committed to a new bailout that is needed by March to avert a default. Euro zone finance ministers were due to decide later Monday on what debt restructuring terms they would accept.

The euro hit its highest level in nearly three weeks against the dollar on optimism a deal would be reached.

U.S. stocks are up nearly 5 percent this year after four days of gains, with investors particularly emboldened by a turnaround in U.S. banking stocks that have helped lead the rally after an abysmal 2011.

A solid showing in fourth-quarter earnings during the current reporting season has also put a floor in the market.

David Lutz, a trader at Stifel Nicolaus Capital Markets in Baltimore, pointed out that some technical analysts are calling for a pullback after the market's strong run.

"Some of the market action to me is showing the possibility of a 'Blowoff Top' this week before we head south of 1,300 again (on the S&P 500)," he said in an email.

The Dow Jones industrial average (.DJI) was up 13.69 points, or 0.11 percent, at 12,734.17. The Standard & Poor's 500 Index (.SPX) was up 3.37 points, or 0.26 percent, at 1,318.75. The Nasdaq Composite Index (.IXIC) was up 8.43 points, or 0.30 percent, at 2,795.13.

The S&P 500 is up more than 22 percent from October lows. The Nasdaq 100 (.NDX) is at its highest level since 2001.

Halliburton Co (HAL.N), the world's second largest oilfield services company, posted quarterly profit that beat analysts' estimates, helped by improved activity in North America. The stock, which has rallied 18 percent since late December, fell 3.6 percent to $34.85.

Research In Motion Ltd's (RIM.TO) (RIMM.O) co-chief executives bowed to investor pressure and resigned over the weekend, handing the top job to an insider with four years at the struggling BlackBerry maker. The stock fell 6 percent to $15.98.

The current earnings season has not been as good as previous ones. Of about 70 companies in the S&P 500 that have reported earnings so far, 60 percent exceeded estimates, according to Thomson Reuters data.

"If earnings come in decently I don't see any type of a big plunge," said Wayne Kaufman, chief market analyst at John Thomas Financial in New York. But, he added, "I'm still concerned about when we get towards the end of earnings season."

Given the recent outperformance of economically sensitive stocks compared to interest rates, Goldman Sachs recommended shorting U.S. 10-year Treasury bonds in anticipation that improved economic performance will push yields higher.

"Yields have traded in a tight range around an average 2 percent since September, including so far into 2012," said Goldman in a research note. "We are now of the view that a break to the upside, to 2.25-2.50 percent, is likely and recommend going tactically short."

Investors in recent weeks have been heartened by improving economic data, even though progress has been uneven.

Chesapeake Energy Corp (CHK.N) will reduce dry gas drilling and cut production in response to natural gas prices falling below "economically unattractive levels". The stocks rose 7.6 percent to $22.54.

(Reporting By Edward Krudy editing by Jeffrey Benkoe)

Source: http://us.rd.yahoo.com/dailynews/rss/stocks/*http%3A//news.yahoo.com/s/nm/20120123/bs_nm/us_markets_stocks

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Romney tries to change the subject from his taxes (AP)

GILBERT, S.C. ? Working to fend off a surging Newt Gingrich in what's become an unexpectedly tight race, presidential candidate Mitt Romney on Friday tried to change the subject from his unreleased tax returns to the ethics investigation Gingrich faced 15 years ago.

Romney's campaign appeared visibly rattled the day before the South Carolina primary, his standing in polls having tumbled after a week of constant attack ads and self-made problems. The former Massachusetts governor faced a potentially difficult day Saturday, and senior aides acknowledged they wouldn't be surprised if he lost the primary.

Romney came to South Carolina after twin victories in Iowa and New Hampshire, only to see his Iowa victory thrown into question because of problems with the count. He's spent a week trying to answer questions about his personal wealth and when he will release his tax returns.

Gingrich's House reprimand in 1997 presented an opportunity to talk about something else. When asked if Gingrich should release the Ethics Committee report that resulted in the first such action against a House speaker, Romney replied, "Of course he should."

"Nancy Pelosi has the full record of that ethics investigation," he said. "You know it's going to get out ahead of the general election."

In fact, the 1,280-page committee report on Gingrich is already public. Campaign officials said Romney was referring to other documents that Gingrich has referenced and that Pelosi has also mentioned.

"Given Speaker Gingrich's newfound interest in disclosure and transparency, and his concern about an `October surprise,' he should authorize the release of the complete record of the ethics proceedings against him," Romney spokeswoman Gail Gitcho said.

Romney's campaign is calling South Carolina voters with a recording attacking Gingrich's ethics record and calling on him to release any documents related to the inquiry.

In December, Pelosi told Talking Points Memo that she had served on the committee that conducted the investigation and implied that more information about the investigation could come to light. At the time Gingrich said the House should retaliate against Pelosi if she released any additional information.

"We turned over 1 million pages of material," Gingrich said then. "We had a huge report."

Gingrich's campaign said Romney's criticism represented a "panic attack" on the part of his campaign.

Romney on Friday said again that he wouldn't release his tax returns until April, which would probably be after Republicans choose their nominee.

"I realize that I had a lot of ground to make up and Speaker Gingrich is from a neighboring state, well-known, popular in the state," Romney said as he campaigned in Gilbert. "Frankly, to be in a neck-and-neck race at this last moment is kind of exciting."

Romney's campaign has rolled out endorsement after endorsement this week as he has tried to build a case that he is the most electable nominee. Ohio Sen. Rob Portman joined him on Thursday and Virginia Gov. Bob McDonnell campaigned with him Friday.

McDonnell said Friday he had been in touch with Romney's campaign for several weeks as they discussed the timing for the endorsement ? and decided it was most needed now, even as Romney looks ahead to a long campaign.

"It's the first Southern primary. I'm a Southern governor. I thought I could help," McDonnell said.

But the campaign's attack message has jumped from rival to rival and topic to topic as Romney's fought to stay afloat here.

At the beginning of the week, Romney was attacking rival Rick Santorum over voting rights for felons. Then he went after Gingrich's claims that he created jobs under President Ronald Reagan, saying Gingrich was living in "fantasyland." Meanwhile, his surrogates held a series of conference calls attacking his rivals, first calling Gingrich an unreliable leader and then pivoting to attack his ethics record.

In Thursday night's GOP debate, Romney continued his string of off-message remarks about his wealth, saying he has lived "in the real streets of America." A multimillionaire, he has three homes, one each in Massachusetts, California and New Hampshire.

Romney held three campaign events Friday in his last-ditch push to stem Gingrich's momentum. After stopping in Gilbert, he held a rally in North Charleston and flew to Greenville in the conservative upstate for a nighttime rally and a stop at his campaign headquarters before an evening event in Columbia, the state capital.

On a plane between events Friday night, Romney was outwardly cheerful in spite of a difficult day ahead, gamely bantering with reporters as he served pastries from Panera Bread.

"Pain au chocolat, smart move!" he said to one, proferring the box and a pair of tongs to take the desserts.

As he moved farther back into the plane, though, he dispensed with the tongs.

"Just use your fingers," he said. "To heck with it!"

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20120121/ap_on_el_pr/us_romney

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Sunday, January 22, 2012

Women in Malawi protest attacks over skirts, pants

(AP) ? It's been 18 years since the late dictator Hastings Kamuzu Banda's "indecency in dress" laws were repealed in Malawi, but mobs of men and boys in the largely conservative southern African country have recently been publicly stripping women of their miniskirts and pants.

Friday, hundreds of outraged girls and women, among them prominent politicians, protested the attacks while wearing pants or miniskirts and T-shirts emblazoned with such slogans as: "Real men don't harass women." A recording of Bob Marley's "No Woman, No Cry" got a loud cheer when it was played during the protest. Men also took part.

"Some of us have spent our entire life fighting for the freedom of women," Vice President Joyce Banda told the protesters. "It's shocking some men want to take us back to bondage."

During Banda's 1963-1994 dictatorship, women in Malawi were banned from wearing pants and short skirts. Banda lost power in the country's first multiparty election in 1994 and died three years later.

"Life President" Banda led the nation to independence from Britain, only to impose an oppressive rule. Whims that reflected a puritanical streak were law. The U.S.-trained physician and former Presbyterian church elder, himself always attired in a dark suit and Homburg hat, also banned long hair on men.

"We fought for a repeal of these laws," Ngeyi Kanyongolo, a law professor, said at Friday's protests. "Women dressed in trousers or miniskirts is a display of the freedom of expression."

While Banda is gone, strains of conservatism remain in the impoverished, largely rural nation. Some of the street vendors who have attacked women in recent days claimed it was un-Malawian to dress in miniskirts and pants. Some said it was a sign of loose morals or prostitution.

The attacks took on such importance, President Bingu wa Mutharika went on state television and radio on the eve of the protest to assure women they were free to wear what they want.

Other African nations, including South Africa, have seen similar attacks and harassment of women. Last year, women and men held "SlutWalks" in South Africa, joining an international campaign against the notion that a woman's appearance can excuse attacks. "SlutWalks" originated in Toronto, Canada, where they were sparked by a police officer's remark that women could avoid being raped by not dressing like "sluts."

In Malawi Friday, protesters also wore T-shirts with the slogan: "Vendor: Today, I bought from you, tomorrow, you undress me?" Street children and vendors have been accused of carrying out the attacks.

The president ordered police to arrest anyone who attacks women wearing pants or miniskirts. Police had already made 15 arrests.

"Women who want to wear trousers should do so as you will be protected from thugs, vendors and terrorists," the president said in a local language, Chichewa. "I will not allow anyone to wake up and go on the streets and start undressing women and girls wearing trousers because that is criminal."

Vice President Banda has speculated the attacks were the result of economic woes in a country that is currently racked by shortages of fuel and foreign currency.

"There is so much suffering that people have decided to vent their frustrations on each other," she told reporters.

A vendors' representative at Friday's protest, Innocent Mussa, was booed off the stage. Mussa insisted those who were harassing women were not true vendors.

"I'm ashamed to be associated with the stripping naked of innocent women," he said. "Those were acts of thugs because a true vendor would want to sell his wares to women, he can't be harassing potential customers."

Mussa blamed the harassment on unemployed young people.

(This version CORRECTS Retransmitting, deletes incorrect reference to South Africa "neighboring" Malawi.)

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-20-AF-Malawi-Women's-Dress/id-5524a2c62d4b41c09ca1a30c263cdd27

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If The Tech Industry Had Its Way, Hollywood Would Be Zynga

Screen Shot 2012-01-20 at 8.27.20 PMLike all of y'all I just read Paul Graham's SOPA-soaked call for a tech startup that would kill Hollywood. ?You would have to be a complete idiot to think Hollywood (or at least some part of Hollywood) isn't ripe for disruption BUT ... "The people who run it are so mean and so politically connected that they could do a lot of damage to civil liberties and the world economy on the way down. It would therefore be a good thing if competitors hastened their demise."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/1p5v7zN5JkI/

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